Spontaneous brain activity is an important biomarker for various neurological and psychological conditions and can be measured using resting functional Magnetic Resonance Imaging (fMRI). Since brain activity during rest is spontaneous, it is not possible to directly compare rfMRI time-courses across subjects. Here we developed a group extension of the pair-wise BrainSync transform (GBS), that jointly synchronizes resting or task fMRI data across time for multiple subjects. Pair-wise Brainsync was applied to bring a group of subjects into alignment with a single representative subject. This tends to bias subsequent analysis towards the individual characteristics of the representative subject. Here we define a group approach in which orthogonal transforms are applied to each subject to match to an unbiased group average.
This page provides a MATLAB implementation of the GBS described in
H. Akrami, A. A. Joshi, J. Li, R. M. Leahy, “Group-wise alignment of resting fMRI in space and time”, Proc. SPIE Medical Imaging 2019: Image Processing, San Diego, CA, Mar. 2019, pp. 737–744.
Please cite the paper above in your publications if you have used GBS in your research.
IN NO EVENT SHALL THE AUTHORS, THE CONTRIBUTORS, THE DISTRIBUTORS AND THE UNIVERSITY OF SOUTHERN CALIFORNIA (“AUTHORS”) BE LIABLE TO ANY PARTY FOR DIRECT, INDIRECT, SPECIAL, INCIDENTAL, OR CONSEQUENTIAL DAMAGES, INCLUDING LOST PROFITS, ARISING OUT OF THE USE OF THIS CODE, EVEN IF THE AUTHORS HAS BEEN ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. THE AUTHORS SPECIFICALLY DISCLAIMS ANY WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE. FOR RESEARCH PURPOSE ONLY. THIS CODE IS PROVIDED ON A “AS IS” BASIS AND THE AUTHORS HAVE NO OBLIGATION TO PROVIDE MAINTENANCE, SUPPORT, UPDATES, ENHANCEMENTS, OR MODIFICATIONS.
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Should you have any questions, please contact Dr. Richard Leahy at leahy sipi DOT usc DOT edu